11 future potential in regenerative medicine and comparisons to human embryonic stem cells
IN VIVO EX VIVO OSTEOGENESIS OF HUMAN EMBRYONIC STEM CELLS
... understanding of the mechanism underlying the lineage specific differentiation of hES cells is mandatory 1.5 Human Embryonic stem cells As the name suggests, the human embryonic stem cells are ... hES cells into osteogenic lineage 18 1.7 In vivo bone formation using Stem Cells 20 MATERIAL & METHODS 23 2.1 Culture and maintenance of Human Embryonic Stem Cells ... other standards in characterizing hES cells (Loring et al 2006) Human embryonic stem cells have shown to retain a stable diploid karyotype and continuously express high levels of telomerase during...
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báo cáo hóa học:" The "Excellence in Translational Medicine" and "Bedside-to-Bench" Awards 2007–08" doc
... http://www.translational -medicine. com/content/7/1/57 swered issues in this emerging basic and clinical research area in animal models and man toward delineating, e.g., the relative effects of T cells and depletion of Tregs In the process, the ... obstacle to immunotherapy Thus, reducing their number or inhibiting their effector functions intuitively has the potential of increasing the efficacy of anti-tumour immunity While increasing preclinical ... will serve to encourage other investigators devoted to improving the "bench -to- bedside" and "bedside -to- bench" concepts of translational medicine and respective initiatives Competition is now...
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Báo cáo hóa học: " The “Excellence in Translational Medicine” and “Bedside-to-Bench” Awards 2008-09" pptx
... management of ART in perinatal HIV-infection With congratulations to Hye-Won Chung [3] and to Raffaele Badolato and their respective co-workers, the 3rd “Excellence in Translational Medicine and 2nd “Bedside -to- Bench” ... and 2nd “Bedside -to- Bench” Awards are now history We are hopeful these Awards will serve to encourage other investigators devoted to improving the “bench-tobedside” and “bedside -to- bench” concepts ... “bedside -to- bench” concepts of translational medicine and respective initiatives *“Excellence in Translational Medicine and Bedsideto-Bench Awards Committee”: Richard J Ablin (CoChairman); Howard L Kaufman;...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... reported in human [16,17] and mouse embryonic stem cells [18-20] The unique patterns of miRNA expression in embryonic stem cells suggest they are involved in maintaining "stemness" Identifying mRNAs ... targeting in human embryonic stem cells [17] In the present study, we applied two custom microarray platforms to detect global expression profiles of miRNAs and transcripts using three hES cell lines, ... the samples into three groups: hES cells, EB, and adult cells Node A contained the genes that were upregulated in both hES cells and EB, node B contained the genes upregulated in hES cells only,...
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Báo cáo khoa học: "In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood" ppt
... lacipyt a si hcihw ,ygolohprom ladiobuc wohs ton did sCSM BCU eht ,sCSM worram enob ekilnu ,revewoH )4 giF( )gniniats assoK-noV yb deifitnedi( laitnetop cinegoetso evah sCSM taht gnitseggus ,etitapayxordyh ... ,etahpsohp lorecylg -β fo detsisnoc taht muidem noitcudni cinegoetso na desu ew ,sCSM eht morf noitaitnereffid cinegoetso ecudni oT laitnetop cinegoetso tibihxe sCSM doolb droC )A2 giF( nitnemiv dna ... morf ,doolb droc aiv ,gnilevart era srotinegorp lamyhcnesem dna citeiopotameh htob taht dezisehtopyh eb nac ti esuaceb lanoitar si doolb droc ni sllec rotinegorp lamyhcnesem fo ecneserp ehT ]12,5[...
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Role of sonic hedgehog signalling in human embryonic stem cells and its neural derivatives
... ligand binds to the Frizzled receptor which allows !-Catenin to translocate to the nucleus and activate transcription FGF2 binds to the FGF receptors (FGFR) and activates the PI3K/Akt and MAP kinase ... ligand binds to the Frizzled receptor which allows !-Catenin to translocate to the nucleus and activate transcription FGF2 binds to the FGF receptors (FGFR) and activates the PI3K/Akt and MAP kinase ... from retinoic acid (RA), Wnt and fibroblast growth factors (FGF) that organize the neural tube into the forebrain, midbrain, hindbrain and spinal cord The Shh and bone morphogenetic proteins (BMP)...
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Human embryonic stem cells as a cellular model for osteogenesis in implant testing and drug discovery
... somatic cells and maintaining normal turnover of regenerative organs such as blood, skin and intestinal tissues 1.2.1 Significance in the use of stem cells: Through research into human growth and ... certain proteins channeled into the cells via poly-arginine anchors and sufficiently induced pluripotency[45] This new technique brings in new hope in stem cell research especially in generating stem ... more on the use of stem cells In addition to biomaterial implants and factors inducing stem cell differentiation towards specific lineages, the emerging field of regenerative medicine requires a...
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báo cáo hóa học:" Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice" docx
... growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regurate normal hematopoiesis in an autocrine/paracrine manner Blood ... Translational Medicine 2008, 6:54 cells, the number (cells/ mm2/mouse) of single stranded DNA (ss-DNA)+ cells in one field in the ischemic core from each mouse in the saline- or hES-ECs+MCs-injected ... Preparation and characterization of transplanted cells derived from human ES cells We induced differentiation of human ES cells in an in vitro two-dimensional culture on OP9 stromal cell line and examined...
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Báo cáo khoa học: "Human embryonic stem cells and therapeutic cloning" pdf
... repair and transplantation medicine There are several approaches in human clinical trails that employ adult stem cells (such as blood-forming hematopoietic stem cells and cartilage-forming cells) ... proteins lost to the meiotic spindle after enucleation However, using a squeezing method, they are Human embryonic stem cells and therapeutic cloning successful in obtaining monkey cloned blastocysts ... supplemented with recombinant leukemia inhibitory factor Human embryonic stem cells and therapeutic cloning (LIF) Dev Biol 1990, 141, 344-352 53 Pera MF, Trounson AO Human embryonic stem cells: prospects...
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Báo cáo y học: "HIV-1 Capsid Assembly Inhibitor (CAI) Peptide: Structural Preferences and Delivery into Human Embryonic Lung Cells and Lymphocyte" pptx
... docking experiments backbone (φ/ψ) and side chain torsions were allowed to rotate (in total 32 torsions which is the maximum number of flexible torsions that AutoDock can handle in the standard installation) ... building blocks using the LEAP module of the AMBER package [30] Linking of the two chains by forming a disulfide bond between the C-terminal cysteines and folding of the molecule into the starting ... a preferred folding of the CAI inhibitor seems to be an important factor for high affinity binding, since the entropic penalty for forming the required conformation on binding to CA is considerably...
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báo cáo khoa học: "Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease" potx
... epigenomics for human disease and regenerative medicine In this section, we envision how recent advances in epigenomics can be used to gain insight into human development and disease, and to facilitate ... Rada-Iglesias A, Wysocka J: Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease Genome Medicine 2011, 3:36 ... regulatory elements CTCF, CCCTC-binding factor, insulator associated protein; ESC, embryonic stem cell; H3K4me1, methylation of lysine of histone H3; H3K4me3, trimethylation of lysine of histone...
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Differentiation and derivation of lineage committed chondroprogenitors and chondrogenic cells from human embryonic stem cells for cartilage tissue engineering and regeneration
... from adult stem cells and mature chondrocytes These include culturing in defined medium to which chondro-inductive cytokines, growth factors and chemicals have been added, co-culturing and the addition ... derived factor - GDF Haematoxylin and eosin - H&E Hours - hr Human- specific vimentin - hVIM Human embryonic stem cells - hESCs Human ESC-derived chondrogenic cell-engineered cartilage - HCCEC Human ... hESCs In the study, hESCs were induced to form EBs in serum-supplemented medium for days prior to dissociation into single cells and co-culturing with human nasal chondrocytes in a transwell insert...
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The derivation, propagation, storage and gene expression of human embryonic stem cells on human feeders
... brain (neuronal stem cells) , skin (epidermal stem cells) , eye (retinal stem cells) and gut (intestinal crypt stem cells) (Spradling et al 2001) However, 15 not all organs and tissues may contain ... cell types in the body There are four classes of pluripotent stem cells in humans, other primates and mice These are embryonic stem cells, embryonic germ cells, embryonic carcinoma cells and recently ... (Ramalho-Santos et al 2002) For obvious ethical reasons, experiments involving blastocyst injections and ectopic grafting in adult hosts cannot be performed in the human Animal embryonic stem cells Embryonic...
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Directed differentiation of human embryonic stem cells into haematopoietic and definitive endodermal lineages
... CHAPTER 1: GENERAL INTRODUCTION 1.1 Embryonic stem cells The isolation of mouse and human embryonic stem cells (ES cells) heralded a new era in regenerative medicine, raising hopes for effective ... Biology 1.3 Regenerative medicine and embryonic stem cells 1.3.1 Diabetes– a candidate disease for cell therapy Autoimmune destruction of insulin-secreting pancreatic β -cells within the Islets ... T cells 14 Figure 1.5 Haematopoietic development Pluripotent stem cells give rise to multipotent haematopoietic stem cells that differentiate into lymphoid and myeloid progenitors T -cells, B-cells...
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Transcriptome study of human embryonic stem cells and knockdown study of a pluripotency marker, LIN28
... IX Introduction 1.1 1.2 Human embryonic stem cells 1.1.1 Overview and characteristics of human embryonic stem cells 1.1.2 Regulatory networks and transcription factors in human ES cells 1.1.3 Induced ... consisting of autoregulatory and feedforward loops to maintain the pluripotency in human ES cells Page Figure Regulatory networks and transcription factors in maintenance of human ES cells bFGF is ... LIN28, an RNA binding protein, contains three RNA binding domains: one coldshock domain at the N terminus and two CCHC-type zinc finger domains at the C terminus It was originally found to regulate...
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Potential applications of chitosan based hydrogels in regenerative medicine
... begins with formation of binding complexes between the growth factors and the receptors on the surface of target cells, resulting in autophosphorylation of the cytoplasmic domains of the receptors ... bone fractures and injuries Mineralized tissues in tooth are found in enamel and dentin (Figure 2.1) Enamel is the outermost part of the tooth and is the hardest mineralized tissue in human body ... attachment study Following the rinsing, each cell-seeded disc was transferred to a 24-well plate and incubated in ml of the growth medium and maintained at 37ºC in the incubator with subsequent...
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Tài liệu Burns Regenerative Medicine and Therapy pdf
... Therapy Regenerative medicine, while a dream in the west, is happily a clinical reality in China We are pleased to be publishing volumes of Regenerative Medicine and Therapy in order to contribute to ... skin; promote stem cells containing the skin information in subcutaneous tissue to regenerate and differentiate to form a skin island; culture the newly regenerated skin island while liquefying ... cultivation by stem cell in vivo and in situ Fig Histological expression process of regeneration and duplication of human skin tissue and organs in vivo and in situ by adult stem cells after burns Introduction...
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Tài liệu An International Perspective on Topics in Sports Medicine and Sports Injury Edited by Kenneth R. Zaslav docx
... Glutamine and Glutamate Reference Intervals as a Clinical Tool to Detect Training Intolerance During Training and Overtraining 41 Rodrigo Hohl, Lỏzaro Alessandro Soares Nunes, Rafael Alkmin Reis, ... interval training, strength training, speed training, skill and tactical training, in various proportions according to the period Rugbymen and rugbywomen underwent an heavy training mostly based ... Nọhrstoffe als Erzeuger der Muskelkraft Pflugers Arch, Vol 83, pp 557-571 2 Glutamine and Glutamate Reference Intervals as a Clinical Tool to Detect Training Intolerance During Training and Overtraining...
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ethical issues in molecular medicine and gene therapy
... IN MOLECULAR MEDICINE AND GENE THERAPY rights to any and all possible benefits medicine may have to offer This, however, brings in another line of moral argument Edward will be denied access to ... conception Germline Engineering Is Too Risky A third objection to germline engineering is related to the second: If we have a morally legitimate objective, such as saving human lives or reducing human ... practice To justify such constraints in a liberal society, we have to be able to point to public interests that would be violated or undermined by that behavior A public interest is an interest...
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báo cáo hóa học: "Advances in wearable technology and applications in physical medicine and rehabilitation" doc
... toward developing ways to record fine motor control tasks involving manipulation of objects requiring fine motor control of the hand and fingers This technology has immediate application in patients ... They range from simple monitoring of daily activities, for the purpose of assessing mobility and level of independence in individuals, to integrating miniature sensors to enhance the function of ... relevant to the application of wearable technology in physical medicine and rehabilitation concerns the integration of wearable sensors into systems Following the seminal work by Park and Jayaraman...
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- morphology of human embryonic stem cells and induced pluripotent stem cells cultured in feeder layer free conditions
- isolation characterization and differentiation of human embryonic stem cells
- human embryonic stem cells international policy and regulation megan allyse and stephen minger
- human embryonic stem cells derivation and culture emma l stephenson peter r braude and chris mason
- successful scale up and quality assessments of human embryonic stem cells for cell therapy challenges and overview
- human embryonic stem cells from laboratory and clinical perspectives
- derivation methods for human embryonic stem cells past present and future pdf
- human embryonic stem cells in drug discovery pdf
- derivation maintenance and characterization of rat embryonic stem cells in vitro pdf
- generation and characterization of monkey embryonic stem cells pdf
- in vitro generation of t lymphocytes from embryonic stem cells pdf
- procedures for derivation and characterisation of human embryonic stem cells from odense denmark
- oct4 klf4 and sox2 in human embryonic stem cells
- role of neuropeptide y on the maintenance of self renewal and proliferation of human embryonic stem cells
- seeding and encapsulation of human mesenchymal stem cells in pec fibers
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